Why drug absorption is important? Drug absorption and bioavailability are essential aspects of pharmacokinetics. They influence drug effectiveness and safety. They can also affect the onset, intensity, and sometimes the duration of action.
What is drug absorption? Drug absorption is the movement of a drug into the bloodstream after administration. (See also Introduction to Administration and Kinetics of Drugs.
What is the most important factor that affects drug absorption? The most important means by which a drug crosses cell membranes is passive diffusion, the rate of which is determined by molecular size, the concentration gradient, lipid solubility, degree of ionization of the drug and protein binding.
What is drug absorption and what factors affect it? Drug absorption depends on the lipid solubility of the drug, its formulation and the route of administration. A drug needs to be lipid soluble to penetrate membranes unless there is an active transport system or it is so small that it can pass through the aqueous channels in the membrane.