Which oncogene is associated with neuroblastoma? Neuroblastoma cells sometimes have extra copies (amplification) of the MYCN oncogene, which is often a sign that the tumor will grow quickly and might be harder to treat.
What chromosome is neuroblastoma located on? Neuroblastoma tumour cells show complex combinations of acquired genetic aberrations, including ploidy changes, deletions of chromosome arms 1p and 11q, amplification of the MYCN oncogene, and—most frequently—gains of chromosome arm 17q.
What is the leading cause of neuroblastoma? The two biggest risk factors for neuroblastoma are age and heredity. Age: Most cases of neuroblastoma are diagnosed in children between the ages of one and two, and 90% are diagnosed before the age of 5. Heredity: 1% to 2% of neuroblastoma cases seem to be the result of a gene inherited from a parent.
What gene is amplified in neuroblastoma? Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous system, is frequently characterized by MYCN gene amplification and high expression of MYCN and c-MYC signature genes.