What size particles can be absorbed through skin? Chemicals that absorb into skin through cells are generally under 500 Dalton. Both beneficial and irritating ingredients can have a molecule size less than 500 Dalton.
What can penetrate your skin?
- Chemical. These include materials such as azone, urea, fatty acids, ethanol, and glycols.
What is the 500 Dalton Rule? We argue that the molecular weight (MW) of a compound must be under 500 Dalton to allow skin absorption. Larger molecules cannot pass the corneal layer. Arguments for this “500 Dalton rule” are; 1) virtually all common contact allergens are under 500 Dalton, larger molecules are not known as contact sensitizers.
Do nanoparticles penetrate the skin? The results of this study showed that nanoparticles were able to passively penetrate the skin and reach the deepest layers of the stratum corneum (SC – the outermost layer of the skin) and hair follicle and, occasionally, reach the viable epidermis.