What are factors affecting percutaneous absorption for topical application? At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application
What factors affect absorption of topical medications?
- Lipid water solubility. Lipid water solubility coefficient is the ratio of dissolution of drug in lipid as compared to water.
- Molecular size.
- Particle size.
- Degree of Ionization.
- Physical Forms.
- Chemical Nature.
- Dosage Forms.
What are the factors affecting skin absorption?
- Molecular weight of the molecule.
- Duration of contact.
- Solubility of substance.
- Physical condition of the skin.
- Part of the body exposed including the amount of hair on the skin.
What is percutaneous absorption? Background: In its simplest definition, percutaneous absorption (PA) is the amount of substance that passes through the stratum corneum compared with the amount applied. The study of the PA of substances is relevant to the fields of dermatopharmacology and occupational medicine.