What are factors affecting percutaneous absorption for topical application?

What are factors affecting percutaneous absorption for topical application? At least 20 clinically relevant factors affect percutaneous absorption of drugs and chemicals: relevant physico-chemical properties, vehicle/formulation, drug exposure conditions (dose, duration, surface area, exposure frequency), skin appendages (hair follicles, glands) as sub-anatomical pathways, skin application

What factors affect absorption of topical medications? 

Factors affecting Absorption of Drugs
  • Lipid water solubility. Lipid water solubility coefficient is the ratio of dissolution of drug in lipid as compared to water.
  • Molecular size.
  • Particle size.
  • Degree of Ionization.
  • Physical Forms.
  • Chemical Nature.
  • Dosage Forms.
  • Formulation.

What are the factors affecting skin absorption? 

Absorption of substances through the skin depends on a number of factors:
  • Concentration.
  • Molecular weight of the molecule.
  • Duration of contact.
  • Solubility of substance.
  • Physical condition of the skin.
  • Part of the body exposed including the amount of hair on the skin.

What is percutaneous absorption? Background: In its simplest definition, percutaneous absorption (PA) is the amount of substance that passes through the stratum corneum compared with the amount applied. The study of the PA of substances is relevant to the fields of dermatopharmacology and occupational medicine.

What are factors affecting percutaneous absorption for topical application? – Additional Questions

What are the three processes of percutaneous absorption?

are three major potential routes of percutaneous penetration: appendageal, transcellular (through the stratum corneum), and intercellular (through the stratum corneum) (Figure 1).

How does percutaneous absorption take place?

Percutaneous absorption occurs after passive diffusion through the different layers of the skin and its appendages. Thereafter, a resorption process into the cutaneous microcirculation brings the compounds into the systemic circulation.

How are topical medications absorbed?

Topical medications are medications applied onto the body to treat various ailments. Most commonly, a topical drug delivery system is applied to the skin, where the medicine either treats only the area of application or is absorbed into the bloodstream through the dermis.

What are the factors affecting drug absorption Slideshare?

Factors affecting absorption of drugs
  • Disintegration Time.
  • Dissolution Time.
  • Manufacturing variables.
  • Pharmaceutical Ingredient.
  • Nature /type of dosage form.
  • Product age and storage condition.

How do you increase transdermal absorption?

Skin Hydration. The water content of the skin plays a vital role in transdermal permeation. Jackson [24] found that hydration of the skin through soaking, moisturizing, or humidity, for example, causes the corneocytes in the SC to swell, which allows molecules to permeate through that layer much easier.

What is a percutaneous drug?

Percutaneous (medications are absorbed directly through the skin into the bloodstream. Some birth control pills and hormone replacements are administered by patches that are absorbed slowly and evenly through the skin, for example.)

What drugs can be absorbed through the skin?

Illicit drugs that some users regularly handle like cocaine, heroin, meth, crack, ecstasy and Ketamine can also be absorbed through the skin if the contact is frequent enough and the drugs are of high potency.

Which administration route provides the greatest drug absorption?

For most drugs the greatest absorption occurs in the small intestine owing to its large surface.

What are the factors affecting drug absorption Slideshare?

Factors affecting absorption of drugs
  • Disintegration Time.
  • Dissolution Time.
  • Manufacturing variables.
  • Pharmaceutical Ingredient.
  • Nature /type of dosage form.
  • Product age and storage condition.

What are 4 factors that affect absorption of a drug?

These include:
  • physicochemical properties (e.g. solubility)
  • drug formulation (e.g. tablets, capsules, solutions)
  • the route of administration (e.g. oral, buccal, sublingual, rectal, parenteral, topical, or inhaled)
  • the rate of gastric emptying.

What are the factors affecting drug absorption and bioavailability?

The lipid solubility, pH of the medium and the presence of and the density of membrane transporters have a greater effect on the rate of absorption. Various routes of drug administration are employed to maximize the amount of drug absorbed and hasten the onset of action of drugs.

What factors affect drug absorption metabolism and elimination?

Factors that affect clearance are: body weight, body surface area, cardiac output, drug-drug interactions, genetics, liver and kidney function, and plasma protein binding.

What factors affect drug absorption quizlet?

Match
  • Surface area.
  • Blood flow.
  • Gastrointestinal motility.
  • Emptying time.
  • Permeability-regional differences.
  • Conc. of drug.
  • Presence & type of food.
  • Stability of drug to enzymes.

What properties of a drug are required for absorption?

For drug absorption to be most efficient, the properties of the drug itself and the pH of the environment where the drug is located must be considered. Most drugs are either weak acids or weak bases. Drugs that are weak acids will pick up a proton when placed in an acidic environment and will, thus, be un-ionized.

Leave a Comment