How can oral bioavailability of drugs be improved? The prodrug design can improve the oral bioavailability of drugs by enhancing their water solubility and gastrointestinal permeability and overcoming first-pass metabolism. Prodrugs can improve the carrier-mediated absorption of charged or polar drugs with negligible passive absorption (Shah et al., 2020).
How can bioavailability be improved? The bioavailability of poorly absorbed drugs can be improved by formulating the drugs into nanosuspensions, solid lipid nanoparticles, polymeric nano- and microparticles, liposomes, niosomes, phytosomes, self-micro emulsifying drug delivery system and microemulsion.
How can enhance bioavailability of active drug by excipients? Lipid-based excipients
Lipid excipients enhance the bioavailability of a poorly soluble drug by keeping it in a liquid form, such as a liquid-filled capsule or solution, until it reaches the site of absorption. These excipients can also influence in vivo processes, absorption barriers, and even the route of absorption.
What factors affect oral bioavailability? Drug bioavailability after oral administration is affected by anumber of different factors, including physicochemical properties of the drug, physiological aspects, the type of dosage form, food intake, biorhythms, and intra- and interindividual variability of the human population.